Sharia in Nederland. Een studie naar islamitische geschilbeslechting bij moslims in Nederland

Contains fulltext : 90171.pdf (publisher's version ) (Open Access)129 p

Vrije wil en verantwoordelijkheid

ARTIKELEN: 1. F. de Jong - Wilsvrijheid en strafrechtelijke verantwoordelijkheid; een rondgang langs fysicalisme, connectionisme en belichaamde 2. D. Roef - Welke vrije wil heeft het strafrecht nodig? Over bewustzijn, brein en capaciteitsverantwoordelijkheid 3. G. Meynen - De psychiater en toerekeningsvatbaarheid 4. N. Vincent - Strafrechtelijke verantwoordelijkheid en de neurowetenschappen 5. W.F.G. Haselager, F. Leoné en D.A.G. van Toor - Data en interpretaties in de cognitieve neurowetenschap 6. B.A.M. van Stokkom - Actieve verantwoordelijkheid in het strafrecht; naar een brede opvatting van ‘recht doen’ 7. M.M. Boone - Vrije wil en verantwoordelijkheid in de strafuitvoering 8. J.A.A.C. Claessen - Strafrecht en Verlichting; over het karakter van een waarlijk verlicht strafrechtssysteem 9. Internetsites. SAMENVATTING: Deze uitgave van Justitiële verkenningen is voor een groot deel gebaseerd op bijdragen die zijn gepresenteerd op de expertmeeting 'Retrospectieve en prospectieve verantwoordelijkheid - schuld, toerekening, vrije wil, gedragsverandering: uitdagingen voor het strafrecht'. De meeting vond plaats op 27 september 2012 en werd georganiseerd door het Willem Pompe Instituut van de Universiteit Utrecht

More right-sided IBD-associated colorectal cancer in patients with primary sclerosing cholangitis.

Contains fulltext : 79676.pdf (publisher's version ) (Closed access)BACKGROUND: Patients with inflammatory bowel disease (IBD) and concurrent primary sclerosing cholangitis (PSC) have a higher risk of developing colorectal cancer (CRC) than IBD patients without PSC. The aim of this study was to investigate potential clinical differences between patients with CRC in IBD and those with CRC in IBD and PSC, as this may lead to improved knowledge of underlying pathophysiological mechanisms of CRC development. METHODS: The retrospective study from 1980-2006 involved 7 Dutch university medical centers. Clinical data were retrieved from cases identified using the national pathology database (PALGA). RESULTS: In total, 27 IBD-CRC patients with PSC (70% male) and 127 IBD-CRC patients without PSC (59% male) were included. CRC-related mortality was not different between groups (30% versus 19%, P = 0.32); however, survival for cases with PSC after diagnosing CRC was lower (5-year survival: 40% versus 75% P = 0.001). Right-sided tumors were more prevalent in the PSC group (67% versus 36%, P = 0.006); adjusted for age, sex, and extent of IBD, this difference remained significant (odds ratio: 4.8, 95% confidence interval [CI] 2.0-11.8). In addition, tumors in individuals with PSC were significantly more advanced. CONCLUSIONS: The right colon is the predilection site for development of colonic malignancies in patients with PSC and IBD. When such patients are diagnosed with cancer they tend to have more advanced tumors than patients with IBD without concurrent PSC, and the overall prognosis is worse. Furthermore, the higher frequency of right-sided tumors in patients with PSC suggests a different pathogenesis between patients with PSC and IBD and those with IBD alone

Primary percutaneous coronary intervention for ST elevation myocardial infarction in octogenarians: trends and outcomes

Objective The general population is gradually ageing in the western world. Therefore, the number of octogenarians undergoing primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) is increasing. We aim to provide insight into temporal trends in the annual proportions of octogenarians among STEMI patients undergoing primary PCI and their clinical characteristics and outcomes over an 11-year observational period. Design Single-centre observational study. Patients Between 1997 and 2007, 4506 STEMI patients were treated with primary PCI at the authors' institution. Patients aged over 80 years were identified. Main outcome measures Temporal trends in the annual proportion of octogenarian STEMI patients and their baseline characteristics, 30-day and 1-year mortality were analysed. Results A total of 379 octogenarians (8.4% of the total population) was treated with primary PCI between 1997 and 2007. Over time, the annual proportion of octogenarians gradually increased from four of 113 (3.5%) in 1997 to 51 of 579 (8.8%) in 2007 (p for trend <0.01). In the total cohort of 379 patients, 30-day mortality was 21% (81 patients) and 1-year mortality was 28% (107 patients). There was no improvement in survival among octogenarian STEMI patients over the 11-year study period. Conclusion The annual proportion of octogenarian STEMI patients increased significantly over the 11-year study period. Mortality among these high-risk patients was high and did not improve during the study period. Unfortunately, little is known about the optimal treatment of the elderly as they are underrepresented in many randomised clinical trials. Further studies into the optimal STEMI management strategy for the elderly are warrante